|New publication: A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors.|
By: Thierry Chénard
November 28 2014
In this article we present the first hand curated metabolite network of one of the most preoccupant nosocomial pathogen, Clostridium difficile. The network correctly reproduces behavior of the bacteria based on comparison with literature’s experimental data and is of similar complexity and completeness than other already published networks. Over 100 potential therapeutic targets were identified and analysed in this paper aiming to find leads for new therapeutic agents to counter C. difficile. Some potentials cross-reactive targets and potentials binders (based on sequence identity with the known target of the drug) were also identified, making it easier to identify the most promising targets to validate and analyse more deeply first.
Larocque M, Chénard C et Najmanovich R: A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors. BMC Syst Biol. 2014, 8(1): 117
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